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. 2024 Jul 2;27(7):1260–1273. doi: 10.1038/s41593-024-01677-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — (a-b) Volcano plot depicting the differentially accessible regions (DARs) (pseudobulk chromatin accessibility at ATAC peaks from multiome data) identified from a pairwise comparisons. (c) Heatmap depicting the log2-fold enrichment of TF motifs in the DARs. (d) UMAP visualization of TF motif activity of the indicated TFs. (e) Motif footprint of Tcf3 normalized for Tn5 insertion bias at the scATAC peaks in the indicated cell type clusters (left) or experimental condition (right). (f) Boxplots depicting the ChromVar deviation values for the indicated TFs in the indicated experimental conditions (n = 708, 708, 732 and 311 cells per condition respectively). Boxplots display median (line), 25th or 75th percentiles (box) as well as 10th or 90th percentiles (whisker).