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. 2024 Jul 2;27(7):1260–1273. doi: 10.1038/s41593-024-01677-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — (a) Schematic representation of the experimental setup (b) Boxplots depicting the ChIP-seq enrichment in reads per million (RPM) at the indicated peak groups (n = 5655, 25352 and 20552 regions respectively). (c) Heatmaps showing ChIP-seq around differentially bound or shared Ngn2/PmutNgn2 peaks. (d) Boxplots depicting normalized accessibility (RPM) at the indicated peak groups (n = 5655, 25352 and 20552 regions respectively). (e) Barplots with mean ± s.d. showing the normalized read counts mapping to either the 5’ or the 3’UTR of the endogenous Ngn2 locus. Dots represent individual biological replicates (n = 3) (f) Heatmaps depicting kmer enrichment in the peak groups shown in Fig. 4a,b, as well as the closest matching TF motif based on similarity. (g) Percentage overlap between peaks and gene promoters ( ± 5 kb from TSS). (h) Percentage of differentially regulated genes (based on bulk RNA-seq) overlapping with different peak categories or genomic features. (i) Percentage of Ngn2/PmutNgn2 peaks overlapping with Rad21 (Cohesin) peaks in the corresponding condition. All boxplots display median (line), 25th or 75th percentiles (box) as well as 10th or 90th percentiles (whisker).