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. 2024 Jul 2;27(7):1260–1273. doi: 10.1038/s41593-024-01677-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — (a) Schematic representation of the experimental setup (b) Pearson’s correlation for ATAC in the indicated experimental conditions (N = 2 biological replicates). (c) Average accessibility (+/- 1 kb) at all TSSs in the indicated experimental conditions. (d) Boxplots depicting the normalized accessibility levels in Yy1WT/KO + Ngn2 conditions at different categories of Yy1 peaks (based on Fig. 7a) grouped by the overlap with Ngn2 binding sites. Boxplots display median (line), 25th or 75th percentiles (box),10th or 90th percentiles (whisker) and outliers (dots) (e-f) Heatmaps depicting the accessibility levels at iN_1 or iN_2 distal enhancers in the indicated experimental conditions. (g) UMAP visualization of the expression levels of Igfbpl1.