Table 2.
Overview of airway function, lung resistance data.
| Lung resistance | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PBS–PBS | LPS–PBS | LPS–PRO | LPS–PRE | LPS–SYN | ||||||
| Basal function | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM |
| 0.82 | 0.056 | 1.16 | 0.12 | 0.92 | 0.097 | 0.89 | 0.08 | 0.76 | 0.041 | |
| Challenge effect (Difference PBS-PBS) | - | 41.47% **** p < 0.0001 |
- | |||||||
| Treatment effect (Difference LPS-PBS) | - | - | −20.67 n.s. | −23.17 n.s. | −34.94*** p = 0.0002 | |||||
| Metacholine (mg/ml; 10% puff; 10s) | ||||||||||
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | |
| 0 | 0.89 | 0.06 | 1.29 | 0.13 | 1.27 | 0.22 | 1.23 | 0.21 | 0.94 | 0.12 |
| 0.38 | 0.95 | 0.07 | 1.51 | 0.17 | 1.37 | 0.25 | 1.34 | 0.22 | 1.03 | 0.16 |
| 0.75 | 1.04 | 0.07 | 1.63 | 0.18 | 1.42 | 0.20 | 1.42 | 0.25 | 1.23 | 0.21 |
| 1.56 | 1.24 | 0.10 | 1.87 | 0.20 | 1.55 | 0.21 | 1.55 | 0.26 | 1.32 | 0.21 |
| 3.13 | 1.32 | 0.11 | 2.05 | 0.21 | 1.74 | 0.27 | 1.71 | 0.26 | 1.49 | 0.21 |
| 6.25 | 1.45 | 0.13 | 2.34 | 0.23 | 1.86 | 0.26 | 1.98 | 0.29 | 1.75 | 0.20 |
| 12.5 | 1.55 | 0.14 | 2.54 | 0.24 | 1.93 | 0.25 | 2.20 | 0.30 | 1.92 | 0.21 |
| 25 | 1.72 | 0.14 | 2.80 | 0.31 | 2.12 | 0.30 | 2.35 | 0.31 | 2.10 | 0.23 |
| Max Challenge effect (Difference PBS-PBS) | - | 62.77%**** p < 0.0001 |
- | |||||||
| Max Treatment effect (Difference LPS-PBS) | - | - | −24.41% n.s. | −16.08% n.s. | −24.98%*** p = 0.0002 |
|||||
| Simple linear regression | ||||||||||
| Equation | Y = 0.1203*X + 0.8483 | Y = 0.2146*X + 1.252 | Y = 0.1223*X + 1.228 | Y = 0.1668*X + 1.139 | Y = 0.1693*X + 0.8811 | |||||
| Goodness of Fit (R squared) | 98.94% | 99.36% | 98.61% | 97.18% | 98.75% | |||||
| Challenge effect (Difference PBS-PBS) | - | p < 0.0001 | ||||||||
| Treatment effect (Difference LPS-PBS) | - | - | p < 0.0001 | p = 0.0042 | p = 0.001 | |||||
ns p > 0.05; *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001.