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. 2024 Jul 11;14:16030. doi: 10.1038/s41598-024-67126-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in the PAM50 signatures in the CORALLEEN and NeoPalAna studies. Schematic summaries of the samples analyzed from (A) the CORALLEEN trial design and (B) the NeoPalAna trial design. (C) Paired samples t-test analyses showing changes in the PAM50 signatures at cycle 1 day 15 (C1D15) in tumor samples from CORALLEEN and (D) NeoPalAna phase II studies. (E) Changes in the PAM50 signatures at surgery in tumor samples from CORALLEEN and (F) NeoPalAna. (G) Changes in the HER2-enriched signature in tumor samples from CORALLEEN and (H) NeoPalAna from patients who underwent surgery ≤ 8 or > 8 days from the last dose of CDK4/6 inhibitors + endocrine therapy.