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. 2024 Jul 11;15:5827. doi: 10.1038/s41467-024-49236-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Schematic illustrating the structure of a liver lobule. b 3,3′-Diaminobenzidine (DAB) stainings of central and portal zone-specific protein expression within healthy tissue hepatocytes. c Gene expression signature of zonation within healthy (right), regenerating (middle), and embolized (left) tissue hepatocytes. Cells in UMAP plots are colored based on the cumulative expression of central (blue) or portal (orange) zonation marker genes. d Pseudozonation expression patterns of representative zonation marker genes for each medical condition. e Histograms showing the proportion of hepatocytes in zonation bins across conditions. f Immunofluorescence tissue staining for liver tissue for various hepatocyte zonation markers. P portal vessel, C central vessel. See also Supplementary Figs. 9, 10. g, Top: Representative H/E stainings showing liver lobule segmentation to measure cell density along a central-to-portal axis; Bottom: Mean ± s.e. for cell density along the central-to-portal axis in each condition. Source data are provided as a Source Data file for (d, e).