Figure 1.

Multitissue transcriptome analysis of nonlesional skin from subjects with AD with and without EH reveals dysregulated epidermal expression among subjects. (a) Heat maps showing LFC in expression between ADEH⁺ (top row) or ADEH⁻ (bottom row) participants compared with HCs for genes differentially expressed in 1 or the other disease group or both (from left to right) in epidermis (top) or dermis (bottom). The genes are organized into broad functional groups. Symbols above heat maps indicate whether (+) or not (−) each gene has been previously associated with AD in nonlesional skin. (b) Scatter plot comparing LFCs between ADEH⁻ and HC epidermal skin with those between ADEH⁺ and HC epidermal skin on the basis of genes with significantly modified expression in ADEH⁺ epidermis compared with that in HCs. Pearson correlation between the 2 sets of LFCs is indicated and demonstrates that genes dysregulated in ADEH⁺ skin are similarly dysregulated in ADEH⁻ individuals. AD, atopic dermatitis; ADEH, atopic dermatitis with eczema herpeticum; EDC, epidermal differentiation complex; EH, eczema herpeticum; HC, healthy control; LFC, log₂ fold change.