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. 2024 Apr 2;4(4):100279. doi: 10.1016/j.xjidi.2024.100279

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© 2024 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

ADEH skin exhibits enhanced viral/IFN inflammation. (a) Box plots of epidermal expression for canonical viral response genes in HC (gray), ADEH⁻ (orange), and ADEH⁺ (red) participants. The asterisk (∗) denotes nominally significant differences (P < .05); the asterisks (∗∗) denote significant differences (FDR < 0.05). (b) ES plot from GSEA visualizing enrichment of ADEH⁺ epidermal DEGs within a gene set preranked on the basis of expression within poly(I:C)-stimulated keratinocytes compared with the controls. Top: running-sum ES profile (brown line) across the poly(I:C)-ranked genes. A subset of leading-edge genes is shown. Middle: positions of ADEH⁺ DEGs along the poly(I:C)-ranked gene list. Bottom: ordered distribution of the gene-ranking statistic (gene deltas). ADEH, atopic dermatitis with eczema herpeticum; DEG, differentially expressed gene; ES, enrichment score; FDR, false discovery rate; GSEA, gene set enrichment analysis; HC, healthy control; Poly(I:C), polyinosinic:polycytidylic acid.