Figure 5.

Subjects with ADEH coexpress multiple inflammatory skin endotypes. (a) Venn diagram of leading-edge genes detected in distinct GSEAs that test for enrichment of epidermal ADEH⁺ DEGs within preranked genes on the basis of T2-high, viral-induced interferon (poly(I:C)-stimulation), and IL-36γ–stimulated inflammation. (b) Pairwise scatter plots of mean expression for distinct leading-edge genes from the 3 inflammatory endotypes (T2, interferon, and IL-36γ). Gray = HC, orange = ADEH⁻, red = ADEH⁺. Dashed lines = the 90^th percentiles of mean expression for HC samples, solid line = slope of the linear relationship, r = Pearson correlation coefficient. (c) The 3D scatter plot of mean expression for distinct leading-edge genes from the 3 inflammatory endotypes. Point colors are as in b. The purple box subsumes all values that are below the 90^th percentile threshold of mean expression for HCs. 3D, 3-dimensional; ADEH, atopic dermatitis with eczema herpeticum; DEG, differentially expressed gene; GSEA, gene set enrichment analysis; HC, healthy control; Poly(I:C), polyinosinic:polycytidylic acid; T2, type 2 cytokine.