Table 3.
Serum Biomarker Concentrations and Parity.
| Marker | n | Nulliparous median (IQR) | n | Parous median (IQR) | p-value | |
|---|---|---|---|---|---|---|
| C3 g/l | Early | 21 | 1.54 (1.46, 1.76) | 51 | 1.60 (1.47, 1.75) | 0.631c |
| Late | 21 | 1.83 (1.69, 1.96) | 51 | 1.82 (1.72, 2.03) | 0.591d | |
| Paired | < 0.001a* | < 0.001a* | ||||
| CRP mg/l | Early | 21 | 3.58 (1.86, 6.29) | 51 | 2.98 (1.87, 5.25) | 0.647f |
| Late | 21 | 3.17 (2.06, 6.05) | 51 | 3.45 (2.21, 5.25) | 0.546d | |
| Paired | 0.714b | 0.159b | ||||
| IL-17A pg/ml | Early | 21 | 0.48 (0.28, 0.90) | 47 | 0.55 (0.22, 0.78) | 0.947e |
| Late | 19 | 0.81 (0.46, 1.26) | 51 | 0.82 (0.45, 1.15) | 0.991d | |
| Paired | 0.030a | 0.005a* | ||||
| IL-6 pg/ml | Early | 20 | 1.17 (0.78, 1.96) | 50 | 1.11 (0.86, 1.33) | 0.161f |
| Late | 21 | 1.76 (1.50, 2.50) | 50 | 1.43 (1.07, 1.79) | 0.197d | |
| Paired | 0.003a* | 0.002a* | ||||
| TNF-α pg/ml | Early | 21 | 7.97 (7.02, 8.63) | 50 | 7.83 (7.36, 8.57) | 0.950e |
| Late | 21 | 8.50 (7.40, 9.75) | 51 | 8.41 (7.47, 9.53) | 0.877d | |
| Paired | 0.039a | 0.003a* | ||||
| CD163 ng/ml | Early | 21 | 364.00 (300.26, 486.88) | 50 | 350.84 (310.38, 415.17) | 0.659e |
| Late | 21 | 517.15 (478.68, 628.10) | 50 | 459.50 (363.76, 558.59) | 0.191d | |
| Paired | < 0.001a* | < 0.001a* | ||||
| ICAM1 ng/ml | Early | 21 | 309.37 (289.70, 348.51) | 50 | 322.75 (272.26, 339.90) | 0.867c |
| Late | 21 | 304.81 (289.86, 356.41) | 51 | 281.76 (242.37, 349.88) | 0.091d | |
| Paired | 0.745b | 0.034b | ||||
| GDF15 ng/ml | Early | 21 | 9.77 (7.67, 10.95) | 50 | 9.16 (7.44, 10.79) | 0.633c |
| Late | 21 | 14.38 (12.34, 18.12) | 51 | 14.91 (12.34, 18.19) | 0.943d | |
| Paired | < 0.001a* | < 0.001a* | ||||
| Leptin ng/ml | Early | 21 | 24.40 (13.97, 39.74) | 50 | 21.50 (16.79, 30.97) | 0.536f |
| Late | 21 | 36.52 (24.61, 47.59) | 51 | 27.39 (15.00, 39.81) | 0.018d* | |
| Paired | 0.001b* | 0.255b |
Comparison of serum concentration values in early and late pregnancy between nulliparous and parous mothers. Parity refers to whether a patient has previously given birth to a neonate. Nulliparous = no previous pregnancies. Parous = had one or more previous pregnancies.
aWilcoxon Rank Sum test on abnormally distributed data.
bPaired t-test on normally distributed data.
cIndependent t-test on normally distributed data.
dp-value generated via Analysis of covariance comparing late pregnancy marker values between parity groups controlled for baseline (early) levels.
eMann-Whitney U test on abnormally distributed data.
fIndependent t-test on normally distributed log-transformed data.
*Significant after Benjamini Hochberg adjustment for multiple comparisons.