Table 2.
Characteristics of current study and 5 recently published clinical sequencing/matching protocols
| Current | Genomes for Kids | INFORM | MAPPYACTS | Pediatric-MATCH | Zero Childhood Cancer | |
|---|---|---|---|---|---|---|
| Patients, n | 888 | 253 | 926 | 624 | 1000 | 247 |
| Age, y | 0–25 | 0–25 | 0–40 | 0–38 | 1–21 | 0–31 |
| Diagnosis Group, % | ||||||
| CNS | 42% | 31% | 27% | 29% | 25% | 37% |
| HM | – | 41% | 9% | 10% | 3% | 17% |
| ST | 58% | 27% | 64% | 61% | 72% | 46% |
| Disease Status, % | ||||||
| Initial diagnosis | 84% | 85% | – | – | – | 47% |
| R/R or high-risk | 14% | 15% | 100% | 100% | 100% | 51% |
| Histologies, n | 95 | 81 | 17 + other | 36 | 80 | 24 + other |
| Type of Sequencing | Panel | WES | WES | WES | Panel | WGS |
| WGS | icWGS | RNAseq | RNAseq | |||
| RNAseq | RNA seq Methylation | Panel | Methylation | |||
| Year Published | 2021 | 2021 | 2022 | 2022 | 2020 | |
| PMID | 3430178829 | 3437326337 | 3529280232 | 3535355330 | 3302065055 | |