Table 1.
Genetic association of rs111337717 and rs116858620 SNP in ATP2B1 gene with severe and asymptomatic cases.
| rs111337717 | Severe cases | Asymptomatic cases | P | OR |
|---|---|---|---|---|
| Genotype | N = 197 | N = 379 | ||
| TT | 165 (0.84) | 345 (0.93) | ||
| CT | 31 (0.15) | 24 (0.06) | ||
| CC | 1 (0.005) | 1 (0.002) | 0.0005a | 2.3 |
| Allele | N.394 | N-740 | ||
| T | 361 (0.92) | 714 (0.96) | ||
| C | 33 (0.08) | 26 (0.03) | 0.0004b | 2.5 |
| rs116858620 | Severe cases | Asymptomatic cases | P | OR |
|---|---|---|---|---|
| Genotype | N = 199 | N = 364 | ||
| TT | 189 (0.95) | 343 (0.94) | ||
| CT | 10 (0.05) | 21 (0.06) | ||
| CC | 0 (0.0) | 0 (0.0) | 0.71 | 0.86 |
| Allele | N = 398 | N = 728 | ||
| T | 388 (0.97) | 707 (0.97) | ||
| C | 10 (0.03) | 21 (0.03) | 0.71 | 0.86 |
The rs111337717 and rs116858620 SNPs in ATP2B1 gene were tested in a cohort of n.197 patients affected by severe COVID-19 and n.370 asymptomatic cases. The minor allele “C” of rs111337717 (NC_000012.12:g.89643729 T > C) with a frequency of 0.03% in our analyzed cohort; SNP [(CACATG(T/C)ACATTAT)] is significantly more frequent among severe COVID-19 cases when compared with asymptomatic individuals (P = 0.0004), thus suggesting rs111337717 SNP could be listed among the genetic risk factor for predisposition to sever COVID-19.
aArmitage trend test: Severe cases vs. Asymptomatic cases.
bFisher’s exact test: severe cases vs. Asymptomatic cases.