Figure 7.

Overall effects of ketamine on responses on the DSST. Ketamine treatment reduced the number of premature responses (A) and increased the number of perseverant responses (B) to the centre nose poke used to initiate trials in both female and male rats. There was a significant increase in the number of errors in the first 6 trials after a rule change (for VCT, FLT, FLT-reversal and VCDT) for female, but not male rats (C). There was no significant effect of ketamine on average response time (D). Within each panel females are shown on the left, and males on the right in response to 0, 3 or 10 mg/kg ketamine. n=40 females and n=41 males, *p<0.05.