Table 1.

Comparison of DrugRepoBank with other 12 drug repositioning databases

	Data amount and features	DrugRepoBank	PharmOmics	DREIMT	DrugSimDB	NeDRex	LINCS Data Portal 2.0	Promiscuous 2.0	EK-DRD	RepurposeDB	repoDB	DrugSig	Promiscuous	Connectivity map
Database	Drugs	49 652	941	0	10 317	13 300	21 231	991 805	1963	253	1571	1300+	25 000	5000
	Targets	4221	18 710	70	0	212 745	0	9430	2985	305	0	800	6500	0
	Drug–target interactions	880 945	0	0	20 061	29 932	0	2 727 520	30 944	0	0	0	21 500	0
	Drug–disease interactions	28 978	0	0	0	0	0	0	0	0	6677	0	0	0
	Drug signature	473 647	14 366	4694	0	36 025	570 862	0	0	0	0	6000	0	1 500 000
	Disease signature	25	0	2687	0	24 120	0	0	0	0	0	0	0	0
	Pathway	6700	0	0	3888	2309	0	0	1332	0	0	0	1600	0
	Side effect	109 698	0	0	139 756	0	0	4964	0	0	0	0	1100	0
	Disease	3379	0	0	10 562	0	0	3379	856	1125	2051	0	0	0
	Predicted targets	Yes	0	0	0	0	0	Yes	0	0	0	0	0	0
	Literature	Yes	No	No	No	No	No	No	Yes	No	No	No	No	No
Network	Network visualization	Interactive	Interactive	None	Interactive	Interactive	None	Interactive	Static	Static	None	None	Interactive	None
Annotation	Functional enrichment analysis	Yes	Yes	Yes	No	Yes	Yes	No	No	Yes	No	No	No	No
Prediction algorithms	Similarity- based algorithm	Yes	No	No	Yes	No	No	Yes	Yes	No	No	No	Yes	No
	Artificial-intelligence- based algorithm	Yes	No	No	No	No	No	Yes	No	No	No	No	No	No
	Signature- based algorithm	Yes	Yes	Yes	No	No	Yes	No	No	No	No	Yes	No	Yes
	Network- based algorithm	Yes	Yes	No	No	Yes	No	No	No	No	No	No	Yes	No
Publications	Year		2022	2021	2021	2021	2020	2020	2019	2018	2017	2017	2010	2006
	Publish journal		iScience	Bioinformatics	Briefing in Bioinformatics	Nature Commun-ications	Nucleic Acids Research	Nucleic Acids Research	Journal of Chemical Information and Modeling	Briefings in Bioinformatics	Scientific data	PLoS One	Nucleic acids Research	Science
	Number of citations (Accessed Google Scholar on 1 September 2023)		5	9	9	28	103	17	5	78	171	47	244	4848
Web interface	Link	https://awi.cuhk.edu.cn/DrugRepoBank	http://mergeomics.research.idre.ucla.edu	http://www.dreimt.org/	http://vafaeelab.com/drugSimDB.html	https://api.nedrex.net	https://lincsportal.ccs.miami.edu/signatures/home	http://bioinformatics.charite.de/promiscuous2	https://www.idruglab.com/drd/index.php	http://repurposedb.dudleylab.org/	http://apps.chiragjpgroup.org/repoDB/	http://biotechlab.fudan.edu.cn/database/drugsig/	http://bioinformatics.charite.de/promiscuous	https://portals.broadinstitute.org/cmap
	Accessibility	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	No	Yes	Yes
Reference			(17)	(16)	(15)	(14)	(13)	(12)	(11)	(10)	(9)	(8)	(7)	(6)