Table 3.

Hazard ratios (95% CIs) for 10-yr incident clinical fragility fracture, MOF, and hip fracture by sedentary behavior in the CaMos cohort ≥50 yr old.

Hazard ratios (ref = First quartile)	Women a			Men b
	Second quartile	Third quartile	Fourth quartile	Second quartile	Third quartile	Fourth quartile
	5.0–6.0 h/d	6.5–8.0 h/d	>8.5 h/d	5.5–7.0 h/d	7.5–9.0 h/d	>9.5 h/d
Any clinical fragility fracture
Unadjusted	1.01 (0.81–1.25)	1.12 (0.90–1.39)	0.97 (0.77–1.23)	1.08 (0.69–1.68)	1.08 (0.67–1.75)	0.75 (0.43–1.29)
Fully adjustedc,d	0.92 (0.74–1.15)	0.98 (0.79–1.23)	0.98 (0.77–1.25)	1.13 (0.72–1.77)	1.14 (0.70–1.86)	0.99 (0.57–1.75)
MOF
Unadjusted	1.03 (0.78–1.35)	1.22 (0.93–1.60)	1.01 (0.74; 1.36)	1.11 (0.61–2.04)	1.07 (0.55–2.09)	0.71 (0.33–1.52)
Fully adjustede,f	0.93 (0.70–1.23)	1.06 (0.80–1.41)	1.05 (0.77; 1.43)	1.09 (0.59–2.02)	1.06 (0.54–2.07)	1.01 (0.46–2.21)
Fragility hip fracture
Unadjusted	0.80 (0.45–1.40)	1.05 (0.61–1.82)	0.86 (0.47–1.60)	0.91 (0.36–2.30)	0.99 (0.37–2.66)	0.59 (0.18–1.91)
Fully adjustedg,h	0.64 (0.36–1.14)	0.83 (0.47–1.45)	0.93 (0.50–1.73)	0.97 (0.39–2.45)	1.07 (0.40–2.88)	1.05 (0.32–3.42)

^aQuartile 1 women: <4.5 h/d of sitting.

^bQuartile 1 men: <5.0 h/d.

Covariates:

^cWomen: age, height, BMI, White, education, center, smoking, physical activity, walking, osteoporosis diagnosis, prior clinical fragility fracture, antiresorptives use, corticosteroids use, CHC, comorbidities.

^dMen: age, height, BMI, physical activity, walking, comorbidities.

^eWomen: age, height, BMI, smoking, physical activity, walking, osteoporosis diagnosis, prior clinical fragility fracture, antiresorptives use, corticosteroids use, hours of sleep, smoking, comorbidities, CHC.

^fMen: age, height, BMI, smoking, physical activity, walking, alcohol, hours of sleep, comorbidities.

^gWomen: age, height, BMI, physical activity, osteoporosis diagnosis, prior clinical fragility fracture, comorbidities, CHC.

^hMen: age, BMI.

MOF, major osteoporotic fracture; CHC, combined hormonal contraceptives.