TABLE 1.
MHC class II DRa and DQa RFLP genotypes and carcinoma development in vaccinated and control rabbits
| Rabbita | RFLP genotypeb
|
Carcinoma development (mo)c | |
|---|---|---|---|
| DRa | DQa | ||
| Vaccinated | |||
| 1 | DD | BCD | − |
| 2 | AD | CDE | − |
| 3 | BD | CD | − |
| 4d | AD | BDE | − |
| 5 | AB | BD | − |
| 6e | BD | BD | − |
| 7 | DD | BD | + (15) |
| 8 | BD | BD | + (12) |
| Control | |||
| 9 | DD | BCD | + (13) |
| 10 | AD | CDE | + (12) |
| 11 | AA | DE | + (13) |
| 12 | AA | DE | + (9) |
| 13 | DD | BCD | + (8) |
| 14 | DD | BCD | + (12) |
| 15 | BB | DE | + (10) |
| 16 | BD | CDE | + (13) |
a
Rabbits were vaccinated with E1, E2, E6, and E7 genes; control rabbits received vector only.
b
DRa and DQa RFLP alleles were named as defined previously (14). DRa alleles were EcoRI fragments of 6.0 (A), 5.6 (B), and 4.8 (D) kb. DQa alleles were PvuII fragments of 6.3 (B), 5.9 (C), 4.8 (D), and 3.0 (E) kb.
c
Carcinoma development (number of months following virus infection).
d
Died 12 months after viral infection without carcinoma development.
e
Died 13 months after viral infection without carcinoma development.