CRC	Colorectal cancer
GTPase	guanosine triphosphatase
5-FU	5-fluorouracil
EGFR	epidermal growth factor receptor
VEGF	vascular endothelial growth factor
RTK	receptor tyrosine kinase
FDA	Food and Drug Administration
KRAS	Kirsten rat sarcoma viral oncogene homolog
BRAF	v-raf murine sarcoma viral oncogene homolog B1
PI3K	phosphatidylinositol-4,5-bisphosphate 3-kinase
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
EMT	epithelial-to-mesenchymal transition
RAC1	Rac family small GTPase 1, Ras-related C3 botulinum toxin substrate 1
GDP	guanosine diphosphate
GTP	guanosine triphosphate
GEF	guanine nucleotide exchange factor
GAP	GTPase activating proteins
GDI	guanine nucleotide-dissociation inhibitors
SRSF1	serine/arginine rich splicing factor 1, SF/AF2
SRp20	serine/arginine rich protein 20, SRSF3
EGF	epidermal growth factor
hnRNP A1	heterogeneous nuclear ribonucleoprotein A1
ESRP1	epithelial splicing regulatory protein 1
LGR5	leucine-rich repeat-containing G protein-coupled receptor 5
APC	adenomatous polyposis coli
ROS	reactive oxygen species
SOX9	SRY-box transcription factor 9
IQGAP1	IQ motif-containing GTPase-activating protein 1
NOX1	NADPH oxidase 1
FOLFOX	leucovorin calcium (folinic acid), fluorouracil, and oxaliplatin
XELOX	capecitabine and oxaliplatin
TCGA	The Cancer Genome Atlas
PAK1	p21 activated kinase
RACK1	receptor for activated kinase 1
STAT	signal transducers and activators of transcription
SOS	son of sevenless
PIP3	phosphatidylinositol (3,4,5)-triphosphate
MET	Mesenchymal–epithelial transition factor receptor
IGF-1R	insulin-like growth factor receptor
HGF	hepatocyte growth factor
3D	three dimensional
LIMK	LIM kinase 1
MMP-3	matrix metalloproteinase 3
CMS	consensus molecular subtypes