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. 2024 Jun 22;16(13):2298. doi: 10.3390/cancers16132298

Figure 3.

Figure 3

Cadherins’ expression subgroups in glioblastoma. (A) Compared to primary tumors, the most frequent subgroups in recurrent tumors are P- and N-cadherin co-expression (46.2%) and N-cadherin expression (30.8%). (B) Tumors with a predominant epithelial component expressed E-cadherin, E- N-cadherin or triple-positive subgroups. For mesenchymal tumors, the subgroups expressed were P- N-cadherin, triple-positive, P-cadherin and N-cadherin. (C) Analysis of data from the TCGA data confirmed a main expression of P- and N-cadherin, N-cadherin, triple-positive and N-cadherin subgroups in the mesenchymal transcriptional subtype. P- and N- co-expression significantly correlated with the mesenchymal subtype (p = 0.033). (D) Tumors from long-term survival patients more frequently exhibited E- and N-cadherin co-expression, N-cadherin, triple-positive or triple-negative subgroups (p = 0.013).