AKT	protein kinase B
cAMP	cyclic adenosine monophosphate
cGMP	cyclic guanosine monophosphate
AD	lung cancer adenocarcinoma
SCC	lung cancer squamous-cell carcinoma
NSCLC	non-small-cell lung cancer
PDE	phosphodiesterase
PDEi	phosphodiesterase inhibitor
PKA	protein kinase A
PKG	protein kinase G
PMX	pemetrexed
TCGA	The Cancer Genome Atlas
WB	Western blotting