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A 3D representation of the homodimeric structures formed by the KRAS4A (Panel A) and KRAS4B (Panel B) isoforms. Notably, both isoforms generate homodimeric structures, but they differ in form. The KRAS4A homodimer is more compact (75.6A) compared to the KRAS4B homodimer (77.96A), which could result in additional steric hindrance affecting the proper positioning of Sotorasib. Panels C and D also show the heterodimeric structures of KRAS4A and KRAS4B.
