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Radiomics workflow. Abbreviations: dLx-Ly, distance between lesion x and lesion y; RF, radiomics features; RTL, radiomics target lesion; IPITH, intra-patient inter-tumor heterogeneity. Regarding the calculation of IPITH metrics, the related scheme has been simplified to a representation of the lesions in a radiomics space of 3 dimensions (i.e., 3 reproducible RFs) to facilitate its understanding, but it actually corresponded to 68 RFs.
