Table 3.
Prognostic factors for patient survival. Univariate and multivariate analyses.
| Events | HR Univariate | HR Multivariate | p | ||
|---|---|---|---|---|---|
| Age (years) | 0.223 | p | |||
| ≤40 | 26 (25.7) | ||||
| >40 | 77 (20.2) | ||||
| Menopausal status | 1 | ||||
| Pre | 53 (21.5) | 0.9 (0.6–1.4) | |||
| Post | 50 (21.3) | Ref | |||
| BRCA carriers | 0.050 | ||||
| Yes | 4 (9.3) | 0.3 (0.1–1.05) | |||
| No | 99 (22.6) | Ref | |||
| TNM anatomic | 0.000 | ||||
| IIA | 12 (9.3) | Ref | |||
| IIB | 48 (24.1) | 2.6 (1.4–5.0) | |||
| IIIA | 18 (22.5) | 2.5 (1.2–5.3) | |||
| IIIB | 19 (30.2) | 3.8 (1.8–7.9) | |||
| IIIC | 6 (54.5) | 9.6 (3.6–25.9) | |||
| TNM prognostic | 0.000 | ||||
| IB | 7 (14) | Ref | |||
| IIA | 25 (17.9) | 1.2 (0.5–2.9) | |||
| IIB | 11 (9.9) | 0.6 (0.2–1.7) | |||
| IIIA | 17 (35.4) | 2.8 (1.1–6.8) | |||
| IIIB | 31 (30.4) | 2.4 (1.0–5.6) | |||
| IIIC | 12 (38.7) | 3.8 (1.5–9.8) | |||
| Pathology subtype | 0.003 | ||||
| Ductal | 92 (20) | Ref | Ref | ||
| Lobular | 8 (57.1) | 3.6 (1.7–7.5) | 4.4 (1.9–10.1) | 0.000 | |
| Others | 3 (33.3) | 1.8 (0.5–5.6) | 1.1 (0.3–3.8) | ||
| Grade | 0.175 | ||||
| I | 3 (15) | Ref | |||
| II | 49 (25.3) | 1.7 (0.5–5.6) | |||
| III | 47 (18.3) | 1.3 (0.4–4.1) | |||
| Ki 67 | 0.125 | ||||
| ≤30% | 49 (24.1) | Ref | |||
| >30% | 54 (19.4) | 0.8 (0.5–1.2) | |||
| Molecular surrogate subtype | 0.074 | ||||
| Luminal A-like | 10 (21.7) | Ref | Ref | ||
| Luminal B-like | 37 (25.7) | 1.2 (0.6–2.5) | 1.4 (0.6–3.2) | ||
| LuminalBHEr2 | 14 (15.4) | 0.7 (0.3–1.6) | 2.1 (0.8–5.6) | ||
| HER2 | 10 (12.8) | 0.6 (0.2–1.4) | 2.5 (0.9–7.3) | ||
| TNBC | 32 (26) | 1.4 (0.7–2.8) | 4.0 (1.3–11.8) | 0.012 | |
| TILs | 0.023 | ||||
| ≤20% | 73 (24.7) | 1.6 (1–2.4) | |||
| >20% | 30 (16) | Ref | |||
| Breast surgery | 0.000 | ||||
| Conservative | 51 (16) | Ref | Ref | ||
| Mastectomy | 52 (31.7) | 2.1 (1.4–3.2) | 2.2 (1.4–3.4) | 0.000 | |
| pCR | 0.000 | a | |||
| Yes | 5 (4.1) | Ref | |||
| No | 98 (27.2) | 7.8 (3.1–19.3) | |||
| RCB | 0.000 | ||||
| 0 | 5 (4.1) | Ref | Ref | ||
| I | 6 (10.5) | 2.8 (0.8–9.2) | 2.2 (0.6–7.3) | ||
| II | 17 (19.8) | 5.4 (2.0–14.8) | 4.4 (1.5–12.8) | 0.006 | |
| III | 75 (34.6) | 10.3 (4.1–25.6) | 8.0 (2.9–21.7) | 0.000 | |
| Vascular invasion | 0.000 | ||||
| No | 61 (16.2) | Ref | Ref | ||
| Yes | 41 (40.6) | 3.1 (2.0–4.6) | 2.4 (1.5–3.7) | 0.000 |
a: grade of freedom limited because covariables are lineally dependent (RCB). Footnotes: HR: Hazard ratio; pCR: pathological complete response; RCB: residual cancer burden; TILs: stromal tumor-infiltrating lymphocytes.