Figure 7.

HDAC inhibition in hcc/hcn-nos cell lines increases cisplatin efficacy in eliminating cancer cells. (A) Images of hcn-nos77, hcc79 and hcc105 cells treated with DMSO, cisplatin, SAHA and cis+SAHA. Scale bars are identical for all images and are shown for the plated cells. (B) Calculations of the number of cells in each group. * shows p < 0.05, ** shows p < 0.01, *** shows p < 0.001, **** shows p < 0.0001, ***** shows p < 0.00001. NS—not significant. (C) Western blot analysis of HDAC1, p21, NeuN and α-SMA in each cell line. The whole gel images of western blots can be found in File S1.