Table 3.
Gene set enrichment analysis. Genes are ordered with increasing p-values.
| Classification | No. of Genes | Fold Enrichment | p-Value | FDR | |
|---|---|---|---|---|---|
| Observed | Expected | ||||
| PANTHER GO-Slim Cellular Component | |||||
| cytosolic ribosome | 10 | 0.95 | 10.53 | 3.74 × 10−8 | 6.13 × 10−6 |
| ribonucleoprotein complex | 21 | 4.77 | 4.4 | 1.55 × 10−8 | 7.64 × 10−6 |
| ribosome | 12 | 1.5 | 8.02 | 3.59 × 10−8 | 8.84 × 10−6 |
| ribosomal subunit | 11 | 1.36 | 8.07 | 1.26 × 10−7 | 1.55 × 10−5 |
| cytoplasm | 91 | 58.09 | 1.57 | 1.77 × 10−6 | 1.75 × 10−4 |
| cytosolic large ribosomal subunit | 6 | 0.56 | 10.74 | 1.92 × 10−5 | 1.57 × 10−3 |
| intracellular anatomical structure | 124 | 93.38 | 1.33 | 4.68 × 10−5 | 3.29 × 10−3 |
| intracellular organelle | 101 | 73.07 | 1.38 | 1.11 × 10−4 | 6.84 × 10−3 |
| large ribosomal subunit | 6 | 0.8 | 7.46 | 1.54 × 10−4 | 8.40 × 10−3 |
| cellular_component | 160 | 132.78 | 1.2 | 2.72 × 10−4 | 1.12 × 10−2 |
| small ribosomal subunit | 5 | 0.56 | 8.95 | 2.34 × 10−4 | 1.15 × 10−2 |
| Unclassified | 70 | 97.22 | 0.72 | 2.72 × 10−4 | 1.22 × 10−2 |
| organelle | 101 | 75.66 | 1.33 | 5.16 × 10−4 | 1.95 × 10−2 |
| cytosolic small ribosomal subunit | 4 | 0.39 | 10.23 | 6.05 × 10−4 | 2.13 × 10−2 |
| cellular anatomical entity | 154 | 129.98 | 1.18 | 1.29 × 10−3 | 4.23 × 10−2 |
| protein-containing complex | 49 | 31.51 | 1.56 | 1.38 × 10−3 | 4.25 × 10−2 |
| PANTHER Protein Class | |||||
| ribosomal protein | 12 | 1.99 | 6.04 | 8.01 × 10−7 | 1.57 × 10−4 |
| translational protein | 14 | 3.74 | 3.74 | 2.62 × 10−5 | 2.57 × 10−3 |
| PANTHER Pathways | |||||
| T cell activation | 7 | 0.94 | 7.46 | 4.32 × 10−5 | 6.96 × 10−3 |
| GO molecular function complete | |||||
| RNA binding | 49 | 18.75 | 2.61 | 3.57 × 10−10 | 1.81 × 10−6 |
| structural constituent of ribosome | 15 | 1.88 | 7.99 | 7.07 × 10−10 | 1.79 × 10−6 |
| binding | 216 | 185.90 | 1.16 | 1.68 × 10−8 | 2.83 × 10−5 |
| protein binding | 196 | 161.51 | 1.21 | 1.34 × 10−7 | 1.70 × 10−4 |
| Unclassified | 6 | 25.60 | 0.23 | 2.43 × 10−6 | 2.47 × 10−3 |
| molecular_function | 224 | 204.40 | 1.10 | 2.43 × 10−6 | 2.06 × 10−3 |
| organic cyclic compound binding | 101 | 68.02 | 1.48 | 3.96 × 10−6 | 2.86 × 10−3 |
| enzyme binding | 46 | 23.61 | 1.95 | 9.00 × 10−6 | 5.71 × 10−3 |
| structural molecule activity | 24 | 8.89 | 2.70 | 1.05 × 10−5 | 5.93 × 10−3 |
| nucleic acid binding | 72 | 45.12 | 1.60 | 2.51 × 10−5 | 1.27 × 10−2 |
| protein-containing complex binding | 40 | 19.97 | 2.00 | 2.60 × 10−5 | 1.20 × 10−2 |
| enzyme regulator activity | 32 | 14.75 | 2.17 | 3.34 × 10−5 | 1.41 × 10−2 |
| mRNA binding | 14 | 3.84 | 3.64 | 3.50 × 10−5 | 1.37 × 10−2 |
| immune receptor activity | 9 | 1.70 | 5.30 | 5.44 × 10−5 | 1.97 × 10−2 |