Table 4.
Odds ratios of the associations between low visual ITH and molecular indicators of heterogeneity in CBCS and TCGA (original only). Clonal/multi-clonal classes are defined based on the number of observed tumor subclonal populations, and TP53 mutations were identified using targeted (CBCS) or whole-exome sequencing (TCGA).
| Clonal | Multi-Clonal | Overall OR (95% CI) | |||
|---|---|---|---|---|---|
| Low Visual ITH | High Visual ITH | Low Visual ITH | High Visual ITH | ||
| Original | 113 (66%) | 77 (55%) | 59 (34%) | 62 (45%) | 1.54 (0.98, 2.45) |
| Stromal | 110 (66%) | 80 (55%) | 56 (34%) | 65 (45%) | 1.60 (1.01, 2.53) |
| Epithelial | 107 (62%) | 83 (60%) | 66 (38%) | 55 (40%) | 1.07 (0.68, 1.70) |
| TCGA | 96 (53%) | 426 (58%) | 86 (47%) | 307 (42%) | 0.80 (0.58, 1.12) |
| TP53 Mutation | No TP53 Mutation | Overall OR (95% CI) | |||
| Low Visual ITH | High Visual ITH | Low Visual ITH | High Visual ITH | ||
| Original | 78 (43%) | 44 (27%) | 105 (57%) | 117 (73%) | 1.98 (1.26, 3.13) |
| Stromal | 74 (41%) | 48 (29%) | 105 (59%) | 117 (71%) | 1.72 (1.10, 2.70) |
| Epithelial | 71 (39%) | 51 (32%) | 113 (61%) | 109 (68%) | 1.34 (0.87, 2.10) |
| TCGA | 64 (35%) | 222 (30%) | 118 (65%) | 511 (70%) | 1.25 (0.89, 1.75) |