Effect of compounds 18c, 18g, and 18h and DMSO on Bax, Bcl-2, and caspases-3/-9 levels inside MDA-MB-231 cells treated with the compounds at their IC50 concentrations.
Gene expression (fold change) | ||||
---|---|---|---|---|
Compound no. | Casp3 | Casp9 | Bax | Bcl2 |
18c | 7.453 | 5.158 | 4.413 | 0.184 |
18g | 3.945 | 4.386 | 3.054 | 0.252 |
18h | 5.559 | 2.799 | 2.154 | 0.423 |
Staurosporine | 7.594 | 5.456 | 6.104 | 0.249 |
Control | 1 | 1 | 1 | 1 |