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. 2024 Jun 24;25(13):6899. doi: 10.3390/ijms25136899

Figure 5.

Figure 5

Synergistic effect of YHB with mTOR/p38 signaling inhibition in PDGF-BB-stimulated VSMCs. (A) Boyden chamber assay showing number of migrated cells. Representative images are shown from at least five independent experiments, taken 8 h after seeding. Scale bar, 200 μm. Magnification, 200×. (B) Effects of YHB with or without MAPK inhibitors on cell proliferation regulatory proteins in PDGF-BB-stimulated VSMCs. Band densities were normalized to those for β-actin. All values are presented as mean ± SD (n = 5). *** p < 0.001 PDGF-BB versus control; ### p < 0.001 YHB versus PDGF-BB alone; $ p < 0.05, $$ p < 0.01, and $$$ p < 0.001 YHB alone versus each inhibitor; † p < 0.05, †† p < 0.01, and ††† p < 0.001 YHB alone versus co-treatment of YHB with each inhibitor; NS, no significance.