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The fate of SCFAs. Following dietary intake of fiber, the digestive process begins in the intestine, (1)where the microbiota produces SCFAs. (2) Colonic cells quickly absorb these compounds and convert them into CO2 and ATP for energy. (3) The unmetabolized SCFA portion reaches the liver, (4) providing energy to hepatocytes and aiding in the synthesis of glucose, cholesterol, and fatty acids. (5) Finally, only a very small part of SCFAs reaches systemic circulation.
