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. 2024 Jun 28;25(13):7143. doi: 10.3390/ijms25137143
AP-1 activating protein-1
Fra-1 (Fosl-1) Fos-related antigen-1
Fra-2 (Fosl-2) Fos-related antigen-2
SSc systemic sclerosis
bZIP basic leucine zipper
TAD trans-activation domain
IHC immunohistochemistry
LIF leukemia inhibitory factor
ChIP chromatin immunoprecipitation
IL interleukin
Fra-2 Tg Fra-2 transgenic
DZNep 3-Deazaneplanocin A
TGF-β transforming growth factor beta
cAMP cyclic adenosine monophosphate
PKA protein kinase A
MAP mitogen-activated protein
JNK c-Jun N-terminal kinase
MEKK1 mitogen-activated protein kinase kinase kinase 1
EMSA electrophoretic mobility shift assay
COPD chronic obstructive pulmonary disease
ECM extracellular matrix
IPF idiopathic pulmonary fibrosis
SSc-PH SSc-associated pulmonary hypertension
α-SMA α-smooth muscle actin
SMCs smooth muscle cells
AT2 cells alveolar type 2 cells
NSIP nonspecific interstitial pneumonia
ColVI collagen type VI
I/R ischemia/reperfusion
Col6α1 collagen type VI alpha 1
TIMP1 tissue inhibitor of metalloproteinase 1
JAK3/STAT5 Janus kinase 3/signal transducer and activator of transcription 5
WT wild-type
Muc5AC mucin 5AC
Col1α2 collagen type I alpha 2
Col6α5 collagen type VI alpha 5
MMP12 matrix metalloproteinases 12
NSCLC non-small cell lung cancer
EMT epithelial–mesenchymal transition
HCC hepatocellular carcinoma
LOXL4 lysine oxidase-like 4
TAMs tumor-associated macrophages
OPN osteopontin
MSCs mesenchymal stem cells
ICOS inducible costimulatory molecule
ECs endothelial cells
ILD interstitial lung disease
UIP usual interstitial pneumonitis
IPAH idiopathic pulmonary arterial hypertension