AP-1 |
activating protein-1 |
Fra-1 (Fosl-1) |
Fos-related antigen-1 |
Fra-2 (Fosl-2) |
Fos-related antigen-2 |
SSc |
systemic sclerosis |
bZIP |
basic leucine zipper |
TAD |
trans-activation domain |
IHC |
immunohistochemistry |
LIF |
leukemia inhibitory factor |
ChIP |
chromatin immunoprecipitation |
IL |
interleukin |
Fra-2 Tg |
Fra-2 transgenic |
DZNep |
3-Deazaneplanocin A |
TGF-β |
transforming growth factor beta |
cAMP |
cyclic adenosine monophosphate |
PKA |
protein kinase A |
MAP |
mitogen-activated protein |
JNK |
c-Jun N-terminal kinase |
MEKK1 |
mitogen-activated protein kinase kinase kinase 1 |
EMSA |
electrophoretic mobility shift assay |
COPD |
chronic obstructive pulmonary disease |
ECM |
extracellular matrix |
IPF |
idiopathic pulmonary fibrosis |
SSc-PH |
SSc-associated pulmonary hypertension |
α-SMA |
α-smooth muscle actin |
SMCs |
smooth muscle cells |
AT2 cells |
alveolar type 2 cells |
NSIP |
nonspecific interstitial pneumonia |
ColVI |
collagen type VI |
I/R |
ischemia/reperfusion |
Col6α1 |
collagen type VI alpha 1 |
TIMP1 |
tissue inhibitor of metalloproteinase 1 |
JAK3/STAT5 |
Janus kinase 3/signal transducer and activator of transcription 5 |
WT |
wild-type |
Muc5AC |
mucin 5AC |
Col1α2 |
collagen type I alpha 2 |
Col6α5 |
collagen type VI alpha 5 |
MMP12 |
matrix metalloproteinases 12 |
NSCLC |
non-small cell lung cancer |
EMT |
epithelial–mesenchymal transition |
HCC |
hepatocellular carcinoma |
LOXL4 |
lysine oxidase-like 4 |
TAMs |
tumor-associated macrophages |
OPN |
osteopontin |
MSCs |
mesenchymal stem cells |
ICOS |
inducible costimulatory molecule |
ECs |
endothelial cells |
ILD |
interstitial lung disease |
UIP |
usual interstitial pneumonitis |
IPAH |
idiopathic pulmonary arterial hypertension |