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Box C/D snoRNA-guided 2′-O-methylation of various RNAs. Once the box C/D snoRNAs are bound to the SNU13 (aka 15.5K), NOP56, NOP58 and FBL proteins to become C/D box snoRNPs, these proteins are guided by snoRNAs to target RNAs and bind to a complementary sequence on the RNA target through a short antisense element. The RNA target then undergoes 2′-O-methylation at a specific site mediated by FBL. Nm modification occurs on various RNA types.
