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. 2024 Jun 25;25(13):6929. doi: 10.3390/ijms25136929

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Discriminatory value of the top 5 genes of splicing machinery components and splicing factors in OSCC (ESRP1, RBM10, ESRP2, RBM3, and NOVA1). (A) VIP scores obtained from Partial Least Squares Discriminant Analysis (PLS-DA) of the spliceosome components analyzed in OSCC vs. non-tumoral adjacent tissues. (B) Unsupervised clustering analysis of mRNA expression levels of the 5 top discriminating spliceosome components and splicing factors (ESRP1, RBM10, ESRP2, RBM3, and NOVA1; shown as a hierarchical heatmap) in OSCC samples (1: shown in green) compared with non-tumoral adjacent tissue (0: shown in red). (C) Receiver operating characteristic (ROC) curve analysis with the expression levels of the 5 top discriminating spliceosome components and splicing factors (ESRP1, RBM10, ESRP2, RBM3, and NOVA1).