Table 3.
In vivo relationship between the expression of spliceosome components in OSCC, staging, and histopathological data. Nonparametric Kruskal-Wallis and U-Mann Whitney tests analyzed the relationship between splicing numerical expression and staging data.
| pT | pTx2 | pN | pNx4 | pN x2 | pN-/pN+ | Stage | Stagex2 | |
|---|---|---|---|---|---|---|---|---|
|
SRSF4
Numerical |
p = 0.41 R 0.04 |
p = 0.37 R 0.15 |
p = 0.12 R −0.19 |
p = 0.09 R −0.18 |
p = 0.98 R −0.01 |
p = 0.29 R −0.18 |
p = 0.64 R 0.07 |
p = 0.87 R 0.27 |
|
SRSF5
Numerical |
p = 0.13 R −0.37 |
p = 0.08 (−) R −0.29 |
p = 0.26 R −0.18 |
p = 0.38 R −0.17 |
p = 0.57 R −0.09 |
p = 0.15 R −0.23 |
p = 0.58 R −0.27 |
p = 0.11 R −0.26 |
|
SRSF9
Numerical |
p = 0.08 (−) R −0.36 |
p = 0.15 R −0.24 |
p = 0.70 R −0.08 |
p = 0.87 R −0.07 |
p = 0.95 R −0.01 |
p = 0.59 R −0.08 |
p = 0.47 R −0.17 |
p = 0.30 R −0.16 |
|
SRSF10
Numerical |
p = 0.23 R 0.09 |
p = 0.49 R 0.12 |
p = 0.11 R −0.02 |
p = 0.33 R −0.01 |
p = 0.44 R 0.14 |
p = 0.80 R −0.04 |
p = 0.13 R 0.16 |
p = 0.80 R 0.04 |
|
NOVA1
Numerical |
p = 0.27 R −0.24 |
p = 0.12 R −0.26 |
p = 0.77 R −0.18 |
p = 0.60 R −0.17 |
p = 0.22 R −0.20 |
p = 0.48 R −0.12 |
p = 0.08 (−) R −0.25 |
p = 0.18 R −0.22 |
|
RBM3
Numerical |
p = 0.88 R −0.07 |
p = 0.90 R −0.02 |
p = 0.13 R −0.16 |
p = 0.12 R −0.16 |
p = 0.88 R 0.02 |
p = 0.18 R −0.23 |
p = 0.42 R −0.05 |
p = 0.51 R −0.11 |
|
RBM10
Numerical |
p = 0.98 R −0.02 |
p = 0.77 R −0.04 |
p = 0.76 R −0.12 |
p = 0.91 R −0.11 |
p = 0.51 R −0.11 |
p = 0.50 R −0.11 |
p = 0.14 R −0.01 |
p = 0.54 R −0.10 |
|
ESRP1
Numerical |
p = 0.12 R −0.01 |
p = 0.57 R 0.09 |
p = 0.12 R −0.01 |
p = 0.40 R 0.03 |
p = 0.35 R 0.15 |
p = 0.89 R −0.02 |
p = 0.02 (+) R 0.11 |
p = 0.46 R 0.12 |
|
ESRP2
Numerical |
p = 0.19 R −0.07 |
p = 0.61 R 0.08 |
p = 0.16 R −0.07 |
p = 0.51 R −0.07 |
p = 0.82 R 0.03 |
p = 0.45 R −0.12 |
p = 0.08 R 0.06 |
p = 0.42 R 0.13 |
|
TRA2A
Numerical |
p = 0.08 (−) R −0.40 |
p = 0.13 R −0.26 |
p = 0.31 R −0.28 |
p = 0.29 R −0.28 |
p = 0.37 R −0.15 |
p = 0.07 (−) R −0.31 |
p = 0.40 R −0.35 |
p = 0.03 (−) R −0.38 |
|
TRA2B
Numerical |
p = 0.40 R −0.25 |
p = 0.16 R −0.24 |
p = 0.28 R −0.34 |
p = 0.19 R −0.33 |
p = 0.17 R −0.23 |
p = 0.06 (−) R −0.33 |
p = 0.71 R −0.26 |
p = 0.09 (−) R −0.28 |
|
TIA1
Numerical |
p = 0.36 R −0.19 |
p = 0.15 R −0.25 |
p = 0.32 R -−0.41 |
p = 0.15 R −0.40 |
p = 0.04 (−) R −0.36 |
p = 0.03 (−) R −0.37 |
p = 0.41 R −0.30 |
p = 0.05 (−) R −0.33 |
| G | DOIx3 | PTI | PTIx2 | PNI | LVI | Invasion Front | Uniformity | |
|
SRSF4
Numerical |
p = 0.21 R −0.21 |
p = 0.80 R 0.06 |
p = 0.27 R 0.23 |
p = 0.10 R 0.28 |
p = 0.84 R -0.03 |
p = 0.91 R −0.01 |
p = 0.48 R 0.12 |
p = 0.48 R 0.12 |
|
SRSF5
Numerical |
p = 1 R 0.00 |
p = 0.24 R −0.27 |
p = 0.06 (+) R 0.39 |
p = 0.01 (+) R 0.41 |
p = 0.23 R −0.15 |
p = 0.56 R −0.09 |
p = 0.81 R 0.03 |
p = 0.81 R 0.03 |
|
SRSF9
Numerical |
p = 0.96 R −0.01 |
p = 0.21 R −0.26 |
p = 0.01 (+) R 0.28 |
p = 0.01 (+) R 0.40 |
p = 0.36 R −0.19 |
p = 0.40 R −0.14 |
p = 0.30 R 0.17 |
p = 0.30 R 0.17 |
|
SRSF10
Numerical |
p = 0.84 R −0.03 |
p = 0.11 R 0.16 |
p = 0.61 R 0.12 |
p = 0.42 R 0.14 |
p = 0.12 R 0.27 |
p = 0.20 R 0.23 |
p = 0.36 R 0.16 |
p = 0.36 R 0.16 |
|
NOVA1
Numerical |
p = 0.24 R −0.19 |
p = 0.39 R −0.14 |
p = 0.11 R 0.21 |
p = 0.16 R 0.24 |
p = 0.88 R 0.02 |
p = 0.76 R −0.05 |
p = 0.04 (+) R 0.34 |
p = 0.04 (+) R 0.34 |
|
RBM3
Numerical |
p = 0.83 R −0.03 |
p = 0.75 R −0.12 |
p = 0.46 R 0.11 |
p = 0.46 R 0.12 |
p = 0.59 R −0.09 |
p = 0.12 R −0.26 |
p = 0.13 R 0.26 |
p = 0.13 R 0.26 |
|
RBM10
Numerical |
p = 0.17 R −0.23 |
p = 0.59 R −0.15 |
p = 0.31 R −0.02 |
p = 0.64 R 0.07 |
p = 0.27 R −0.18 |
p = 0.26 R −0.18 |
p = 0.65 R 0.07 |
p = 0.65 R 0.07 |
|
ESRP1
Numerical |
p = 0.69 R −0.06 |
p = 0.82 R −0.04 |
p = 0.56 R 0.04 |
p = 0.73 R 0.05 |
p = 0.69 R 0.06 |
p = 0.57 R −0.09 |
p = 0.12 R 0.26 |
p = 0.12 R 0.26 |
|
ESRP2
Numerical |
p = 0.78 R −0.04 |
p = 0.68 R −0.14 |
p = 0.47 R 0.13 |
p = 0.31 R 0.17 |
p = 0.66 R −0.07 |
p = 0.43 R −0.13 |
p = 0.06 (+) R 0.30 |
p = 0.06 (+) R 0.30 |
|
TRA2A
Numerical |
p = 0.80 R 0.04 |
p = 0.22 R −0.29 |
p = 0.17 R 0.24 |
p = 0.06 R 0.32 |
p = 0.87 R 0.02 |
p = 0.66 R 0.07 |
p = 0.80 R −0.04 |
p = 0.80 R −0.04 |
|
TRA2B
Numerical |
p = 0.01 (−) R −0.43 |
p = 0.24 R −0.29 |
p = 0.03 (+) R 0.40 |
p < 0.01 (+) R 0.46 |
p = 0.49 R −0.11 |
p = 0.62 R 0.08 |
p = 0.25 R 0.19 |
p = 0.25 R 0.19 |
|
TIA1
Numerical |
p = 0.06 (−) R −0.33 |
p = 0.04 (−) R −0.44 |
p = 0.04 (+) R 0.35 |
p = 0.01 (+) R 0.45 |
p = 0.27 R −0.19 |
p = 0.91 R 0.01 |
p = 0.68 R −0.07 |
p = 0.68 R −0.07 |
Abbreviations: DOI, Depth of Invasion; DOIx3 (1–5 mm, 5–10 mm. >10mm); G, grade; Invasion front [expansive (+) vs. infiltrative (−)]; LVI, lymphovascular invasion; pN, cervical metastasis (pN0/pN1/pN2a/pN2b/pN3); pNx4 (pN0/pN1/pN2/pN3); pNx2 (pN0 + pN1/pN2 + pN3), pN- (pN0) vs. pN+ (pN1, pN2, pN3); PNI, perineural invasion; pT, tumor size (pT1, pT2, pT3, pT4); pTx2 (pT1 + pT2/pT3 + pT4); PTI (mild, moderate, severe), PTIx2 (absent + mild/moderate + severe); Stage (I/II/III/IV); Stage x2 (I + II/III +/IV); Uniformity [poorly defined tumor edges (−) vs. well-defined edges (+)]; (−), negative correlation; (+), positive correlation.