Table 1.
Age-related changes in aging markers in mouse skeletal muscle.
| 4 Weeks | 55 Weeks | 110 Weeks | p | |
|---|---|---|---|---|
| MDA (μg/g) | 10.3 ± 0.08 | 12.2 ± 0.3 | 14.9 ± 0.3 | <0.0001 |
| 4HNE (ng/g) | 55 ± 0.4 | 64 ± 0.7 | 74 ± 1.9 | <0.0001 |
| AGE (ng/g) | 101 ± 1.1 | 108.3 ± 2.1 | 113.0 ± 3.1 | <0.0001 |
| HMGB1 (μg/g) | 5.2 ± 0.8 | 7.2 ± 0.8 | 13.0 ± 1.2 | <0.0001 |
| COL (μg/g) | 26 ± 0.3 | 28 ± 0.4 | 30 ± 0.6 | <0.0001 |
| TV (%) | 100.0 ± 0.7 | 95.0 ± 1.2 | 88.2 ± 1.3 | <0.0001 |
| βGAL (ng/g) | 7.6 ± 0.08 | 7.8 ± 0.06 | 8.6 ± 0.14 | <0.0001 |
| SDS-MYL1 (pg/g) | 108 ± 0.8 | 105 ± 0.7 | 92 ± 0.9 | <0.0001 |
| Ki67 (pg/g) | 11 ± 0.1 | 10 ± 0.1 | 9.3 ± 0.1 | <0.0001 |
Changes in the levels of aging markers in mouse quadriceps femoris (QCM) samples at 4, 55, and 110 weeks of age. Statistical differences (among three groups) were calculated by ordinal analysis of variance (ANOVA) with Bonferroni correction. MDA, malondialdehyde; 4HNE, 4-hydroxynonenal; AGE, advanced glycation end products; HMGB1, high-mobility group box-1; COL, collagen III; TV, telomere volume; βGAL, beta-galactosidase; SDS-MYL1, sodium dodecyl sulfate-soluble myosin light chain-1.