Table 2.
Results of CD4/CD8 ratio ≤1.0 with histopathological findings. p > 0.05 was considered statistically significant at the 95% confidence interval.
| CD4/CD8 ≤ 1.0 vs. Perivascular Infiltrates | CD4/CD8 ≤ 1.0 vs. Parenchyma Infiltrates |
CD4/CD8 ≤ 1.0 vs. Cell Activation and Death |
|||
|---|---|---|---|---|---|
| Non-induced | p | Non-induced | p | Non-induced | p |
| Mild (+) | 0.030 | Mild (+) | 0.022 | Microglia | 0.133 |
| Moderate (++) | 0.035 | Moderate (++) | 0.041 | Astrocyte | 0.231 |
| Severe (+++) | 0.346 | Severe (+++) | 0.046 | Cell death | 0.255 |
| Sham | p | Sham | p | Sham | p |
| Mild (+) | 0.257 | Mild (+) | 0.022 | Microglia | 0.011 |
| Moderate (++) | 0.379 | Moderate (++) | 0.017 | Astrocyte | 0.025 |
| Severe (+++) | 0.455 | Severe (+++) | 0.012 | Cell death | 0.270 |
| WJ-MSC | p | WJ-MSC | p | WJ-MSC | p |
| Mild (+) | 0.222 | Mild (+) | 0.350 | Microglia | 0.366 |
| Moderate (++) | 0.235 | Moderate (++) | 0.466 | Astrocyte | 0.247 |
| Severe (+++) | 0.044 | Severe (+++) | 0.688 | Cell death | 0.577 |
| NP | p | NP | p | NP | p |
| Mild (+) | 0.034 | Mild (+) | 0.112 | Microglia | 0.038 |
| Moderate (++) | 0.047 | Moderate (++) | 0.024 | Astrocyte | 0.333 |
| Severe (+++) | 0.049 | Severe (+++) | 0.042 | Cell death | 0.421 |
| WJ-MSC+NP | p | WJ-MSC+NP | p | WJ-MSC+NP | p |
| Mild (+) | 0.012 | Mild (+) | 0.242 | Microglia | 0.455 |
| Moderate (++) | 0.037 | Moderate (++) | 0.445 | Astrocyte | 0.587 |
| Severe (+++) | 0.299 | Severe (+++) | 0.032 | Cell death | 0.592 |
Non-induced group (N-I), Wharton’s jelly mesenchymal stem cells (WJ-MSCs), and neural precursors (NPs).