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. 2024 Jun 29;25(13):7206. doi: 10.3390/ijms25137206

Figure 7.

Figure 7

A schematic illustration of SRI regulating apoptosis in HCC. SRI overexpression inhibits the apoptosis of HCC cells by interacting with STAT3 via NF-κB pathway, whereas opposing effects were observed for knockdown of SRI. Stattic, an inhibitor of STAT3, promotes apoptosis of HCC cells via NF-κB pathway. Avicularin, the inhibitor of NF-κB, which promotes apoptosis of HCC cells. : represent upregulation or promotion. : represent downregulation or inhibition.