Table 2.

Stromal TILs (sTILs): evidence suggests an overall increase in sTILs following neoadjuvant chemotherapy (NACT), but with highly variable individual patient responses and significant prognostic implications for progression-free survival (PFS).

Stromal	Prognostic Association Pre-NACT	Prognostic Association Post-NACT	Study
TILs	PFS increase with ↑	PFS increase with ↑	Mesnage et al. [26]
	None	None	Kim et al. [27]
	PFS increase with ↑ OS increase with ↑	None	Lee et al. [31]
CD8+	None	None	Leary et al. [29]
	PFS increase with ↑ OS increase with ↑	None	Lee et al. [31]
CD3+	None	None	Leary et al. [29]
CD4+	None	None	Leary et al. [29]
	None	None	Bohm et al. [24]
Foxp3+	None	PFS increase with ↑ OS none	Leary et al. [29]
	PFS increase with ↑ OS increase with ↑	None	Lee et al. [31]