Table 3.

Intraepithelial TILs (ieTILs): 33% of patients had increased intraepithelial TILs (ieTILs) following neoadjuvant chemotherapy (NACT). In contrast, low Foxp3+ cell density post-NACT was associated with longer progression-free survival and overall survival.

Tumor	Prognostic Association Pre-NACT	Prognostic Association Post-NACT	Study
TILs	None	None	Mesnage et al. [26]
CD8+	None	None	Polcher et al. [23]
	None	None	Lo et al. [25]
	None	None	Leary et al. [29]
CD3+	None	None	Lo et al. [25]
	None	None	Leary et al. [29]
CD4+	None	None	Polcher et al. [23]
	None	None	Leary et al. [29]
Foxp3+	None	PFS increase with ↓ OS increase with ↓	Polcher et al. [23]
	None	None	Lo et al. [25]
	None	None	Leary et al. [29]
CD20+	None	PFS none OS increase with ↑	Lo et al. [25]
CD8+/Foxp3+	None	None	Polcher et al. [23]
CD8+/CD4+	None	PFS none OS increase with ↑	Polcher et al. [23]