Table 4.

PD-1 and PD-L1 expression, cytokine expression, and other immune checkpoint targets.

	Prognostic Association Pre-NACT	Prognostic Association Post-NACT	Study
Granzime B+	None	PFS increase with ↑ OS none	Polcher et al. [23]
GranzymeB/Foxp3	None	PFS increase with ↑ OS none	Polcher et al. [23]
PD-L1	None	None	Mesnage et al. [26]
	None	None	Kim et al. [27]
	None	None	Bohm et al. [24]
	None	None	Lo et al. [25]
	None	PFS increase with ↑ OS increase with ↑	Chen et al. [28]
	None	None	Félix Blanc-Durand et al. [30]
	PFS increase with ↑ OS increase with ↑	None	Lee et al. [31]
PD-1	None	None	Lo et al. [25]
IDO-1	None	None	Félix Blanc-Durand et al. [30]
TIM3+	None	None	Félix Blanc-Durand et al. [30]
LAG3+	None	None	Félix Blanc-Durand et al. [30]