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. 2024 Jun 30;25(13):7229. doi: 10.3390/ijms25137229

Table 1.

Direct interacting partners of miR-137 identified in neurodegenerative disorders.

Abbreviation Name Biological Role 1 Interaction
Effect		 Interaction Implicated
in 2 		Ref.
CACNA1C Calcium Voltage-Gated Channel Subunit Alpha1 C subunit of a voltage-dependent L-type Ca2+ channel downregulated by miR-137-3p AD [51]
MAGL Monoacylglycerol lipase hydrolyzes monoacylglycerides, including the brain endocannabinoid, 2-arachidonoylglycerol downregulated by rno-miR-137 AD [49]
PTN Pleiotrophin a neurotrophic factor involved in neural development and inflammation downregulated by miR-137-3p AD [50]
SPTLC1 Serine palmitoyltransferase long-chain base subunit 1 subunit of serine palmitoyltransferase, a rate-limiting enzyme in de novo ceramide synthesis downregulated by miR-137 AD [37]
USP30 Ubiquitin-specific peptidase 30 mitochondrial deubiquitinase enzyme downregulated by miR-137 AD [44] 3
KREMEN1 Kringle-Containing Transmembrane Protein 1 Wnt antagonist, prevents glycogen synthase kinase-3 beta sequestration downregulated by miR-137-3p AD [48]
NIX/BNIP3L NIP3-Like Protein X/
Bcl-2/adenovirus E1B 19-kDa-interacting protein 3-like		 mitophagy receptor downregulated by miR-137-3p PD [52]
OXR1 Oxidation resistance 1 positively affects oxidative stress resistance, has protective effects against ROS downregulated by miR-137-3p PD [53]
HTT Huntingtin affects vesicular trafficking, transcription, and apoptosis, mutated in HD downregulated by miR-137-3p HD [54]
SNHG1 Small nucleolar RNA host gene 1 ceRNA depletes miR-137-3p AD [48]
SNHG19 Small nucleolar RNA host gene 1 ceRNA depletes miR-137-3p AD [55]
OIP5-AS1 Opa-interacting protein 5 antisense RNA 1 ceRNA depletes miR-137-3p PD [52]
GAS5 Growth arrest-specific 5 ceRNA depletes miR-137-3p MS [56]

1 ceRNA: Competing endogenous RNA. 2 AD: Alzheimer’s disease, PD: Parkinson’s disease, HD: Huntington’s disease, and MS: multiple sclerosis. 3 The referenced paper reports the interaction of the 3′-UTR of USP-30 and miR-137-5p, but the presented sequence corresponds to miR-137-3p.