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. 2024 Jun 21;25(13):6832. doi: 10.3390/ijms25136832

Figure 2.

Figure 2

Figure 2

Genetic variants of SCN11A, SCN10A, and SCN9A identified in this study and their location in the Nav1.9, Nav1.8, and Nav1.7. Nav1.9, Nav1.8, and Nav1.7 have four domains (DI~DIV), each of which consistent of six transmembrane segments. Genetic variants are shown in schematic diagrams for Nav1.9 (a), 1,8 (b), and 1.7 (c), respectively. The color of each variant indicates its rating, based on the American College of Medical Genetics and Genomics standards and guidelines for interpreting sequence variants. Red represents “pathogenic,” purple represents “likely pathogenic,” green represents “likely benign,” and light blue represents “VUS”.