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Transformation of flavonoids 120a–c yielding methoxymethyl–morpholinomethyl derivatives: condition (a) MeOH, 2.5 equiv. HCHO, 0.8 equiv. N-Me-piperazine, 63 °C, 1 h; condition (b) MeOH, 1.5 equiv. HCHO, 1.5 equiv. N-Me-piperazine, 20 °C, 12 h; condition (c) MeOH, 2.0 equiv. HCHO, 1.2 equiv. N-Me-piperazine, 46 °C, 6 h.
