Table 1.
Baseline and cycle characteristics of patients with adenomyosis undergoing either atosiban administration or no administration during frozen embryo transfer
| Parameters | Atosiban (n = 168) | Control (n = 168) | p value |
|---|---|---|---|
| Age (years) | 37.9 ± 4.2 | 38.2 ± 3.8 | 0.531 |
| Body mass index (kg/m2) | 23.7 ± 3.9 | 23.7 ± 4.3 | 0.970 |
| Infertility duration (years) | 4.7 ± 3.2 | 5.3 ± 3.7 | 0.102 |
| Previous IVF attempts (n) | 2.9 ± 2.5 | 3.1 ± 2.3 | 0.296 |
| Types of infertility (%) | 0.913 | ||
| Primary infertility | 47.0%(79/168) | 47.6%(80/168) | |
| Secondary infertility | 53.0%(89/168) | 50.3%(88/168) | |
| Causes of infertility | 0.817 | ||
| PCOS | 13.7%(23/168) | 9.5%(16/168) | |
| Tubal factors | 8.9%(15/168) | 10.1%(17/168) | |
| Male factors | 8.9%(15/168) | 11.3%(19/168) | |
| DOR | 22.6%(38/168) | 25.0%(42/168) | |
| Unexplained | 13.7%(23/168) | 14.3%(24/168) | |
| Multiple | 32.1%(54/168) | 29.8%(50/168) | |
| FSH (IU/L) | 5.5 ± 2.9 | 5.1 ± 2.9 | 0.163 |
| Anti-Müllerian hormone (ng/mL) | 3.36 ± 3.47 | 3.37 ± 2.87 | 0.963 |
| Endometrial thickness (mm) | 11.7 ± 2.3 | 11.6 ± 2.2 | 0.884 |
| ET day (%) | 0.258 | ||
| Day 3 ET | 60.1% (101/168) | 66.1% (111/168) | |
| Day 5 ET | 39.9% (67/168) | 33.9% (57/168) | |
| Number of transferred embryos (%) | 0.308 | ||
| 1 embryo | 13.7% (23/168) | 11.9% (20/168) | |
| 2 embryos | 58.3% (98/168) | 50.6% (85/168) | |
| 3 embryos | 17.9% (30/168) | 22.6% (38/168) | |
| 4 embryos | 10.1% (17/168) | 14.9% (25/168) | |
| At least one top-quality embryos transferred (%) | 79.2% (133/168) | 78.6% (132/168) | 0.894 |
| Biochemical pregnancy rate (%) | 58.9% (99/168) | 48.2% (81/168) | 0.049 |
| Clinical pregnancy rate (%) | 51.2% (86/168) | 47.0% (79/168) | 0.445 |
| Ongoing pregnancy rate (%) | 47.0% (79/168) | 36.9% (62/168) | 0.060 |
| Live birth rate (%) | 44.0% (74/168) | 35.1% (59/168) | 0.094 |
| Miscarriage rate (%) | 14.0% (12/86) | 25.3% (20/79) | 0.065 |
| Early miscarriage rate (%) | 8.1% (7/86) | 21.5% (17/79) | 0.015 |
| Late miscarriage rate (%) | 5.8% (5/86) | 3.8% (3/79) | 0.547 |
Data are presented as the mean ± standard deviation and %
IVF, in vitro fertilization; PCOS, polycystic ovary syndrome; DOR, diminished ovarian reserve; FSH, follicular stimulating hormone; ET, embryo transfer