Table 3.
Subgroup analysis of patients with adenomyosis stratified by age and atosiban administration
| Age < 37 years (n = 116) | Age ≧ 37 years (n = 220) | |||||
|---|---|---|---|---|---|---|
| Parameters | Atosiban (n = 54) | Control (n = 62) | p value | Atosiban (n = 114) | Control (n = 106) | p value |
| Age (years) | 32.8 ± 2.3 | 34.1 ± 1.7 | 0.001 | 40.3 ± 2.3 | 40.6 ± 2.3 | 0.426 |
| Body mass index (kg/m2) | 23.9 ± 3.9 | 22.9 ± 4.4 | 0.198 | 23.6 ± 3.9 | 24.2 ± 4.3 | 0.283 |
| Infertility duration (years) | 3.1 ± 2.1 | 4.5 ± 2.5 | 0.002 | 5.5 ± 3.4 | 5.8 ± 4.1 | 0.487 |
| Previous IVF attempts (n) | 1.7 ± 1.1 | 2.3 ± 1.6 | 0.012 | 3.4 ± 2.7 | 3.6 ± 2.5 | 0.586 |
| Primary infertility (%) | 64.8%(35/54) | 50.0%(31/62) | 0.108 | 38.6%(44/114) | 46.2%(49/106) | 0.252 |
| FSH (IU/L) | 5.0 ± 2.4 | 5.2 ± 2.9 | 0.814 | 5.8 ± 3.2 | 5.0 ± 2.9 | 0.076 |
| Anti-Müllerian hormone (ng/ml) | 5.72 ± 4.35 | 5.11 ± 3.17 | 0.385 | 2.24 ± 2.24 | 2.36 ± 2.11 | 0.682 |
| Endometrial thickness (mm) | 11.7 ± 2.3 | 11.8 ± 2.3 | 0.869 | 11.6 ± 2.3 | 11.5 ± 2.1 | 0.734 |
| ET day (%) | 0.002 | 0.523 | ||||
| Day 3 ET | 31.5%(17/54) | 59.7%(37/62) | 73.7%(84/114) | 69.8%(74/106) | ||
| Day 5 ET | 68.5%(37/54) | 40.3%(25/62) | 26.3%(30/114) | 30.2%(32/106) | ||
| At least one top-quality embryos transferred (%) | 70.4%(38/54) | 80.6%(50/62) | 0.197 | 83.3%(95/114) | 77.4%(82/106) | 0.264 |
| Biochemical pregnancy rate (%) | 70.4%(38/54) | 56.5%(35/62) | 0.122 | 53.5%(61/114) | 43.4%(46/106) | 0.134 |
| Clinical pregnancy rate (%) | 64.8%(35/54) | 54.8%(34/62) | 0.275 | 44.7%(51/114) | 42.5%(45/106) | 0.733 |
| Ongoing pregnancy rate (%) | 61.1%(33/54) | 51.6%(32/62) | 0.304 | 40.4%(46/114) | 28.3%(30/106) | 0.060 |
| Live birth rate (%) | 61.1%(33/54) | 48.4%(30/62) | 0.170 | 36.0%(41/114) | 27.4%(29/106) | 0.171 |
| Miscarriage rate (%) | 5.7%(2/35) | 11.8%(4/34) | 0.373 | 19.6%(10/51) | 35.6%(16/45) | 0.079 |
| Early miscarriage rate (%) | 5.7%(2/35) | 5.9%(2/34) | 0.976 | 9.8%(5/51) | 33.3%(15/45) | 0.005 |
| Late miscarriage rate (%) | 0.0%(0/35) | 5.9%(2/34) | 0.145 | 9.8%(5/51) | 2.2%(1/45) | 0.126 |
Data are presented as the mean ± standard deviation and % (n)
IVF, in vitro fertilization; FSH, follicular stimulating hormone; ET, embryo transfer