Table 2.

Human and animal experimental techniques used to study the role of glucagon-like peptide (GLP-1) in headache and pain disorders

	Animal studies	Human studies
Inflammatory pain	Mouse model of sodium monoiodoacetate osteoarthritis	Randomized, placebo-controlled trial
	Carrageenan-induced, formalin-induced and Complete Freund´s Adjuvant (CFA)-induced peripheral inflammation	Prospective observational study
Headaches	Hydrocephalus rat model with raised intracranial pressure	Randomized, placebo-controlled trial
	Nitroglycerin-induced model of migraine	Case-control study
Neuropathic pain	Formalin tests
	Bone cancer pain model
	Spared nerve injury, partial sciatic nerve transection and spinal nerve ligation models
	Nicotinamide- and streptozotocin-induced model of diabetic pain
Visceral pain	Model of visceral hypersensitivity induced by lipopolysaccharide, repeated water avoidance stress and intra-colonic infusion of acetic acid	Randomized, placebo-controlled trial
	Model of irritable bowel syndrome