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Cyclo (l-Pro-l-Val) and cyclo(l-Pro-L-Leu) did not show tyrosinase inhibitory activity. Tyrosinase activity was evaluated by measuring absorbance at 492 nm. Commercially available cyclo(l-Pro-l-Tyr), cyclo (l-Pro-l-Val) and cyclo(l-Pro-L-Leu) were treated with 12 mM tyrosinase. Control: tyrosinase treated with phosphate-buffered saline (PBS) (negative control); HA: tyrosinase treated with 2 mM homogentisic acid (positive control); bars: standard deviation (SD), *** p < 0.001.
