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Scheme of ADAR1-mediated A>I(G) RNA editing. (A) ADAR1 activity function in DNA damage repair machinery such as ATM, ATR, GINS4, POLH, ZEB1, and CtIP from double-strand DNA breaks (DSB); (B) effect of ADAR1-mediated A>I(G) RNA-edited dsRNA and non-edited dsRNA on MDA5/MAVS/PKR function and I Interferon-Stimulated Genes (ISGs). Adapted from Nakahama T. and Kawahara Y. [30].
