Table 1.
A>I(G) RNA-edited sites involved in the carcinogenic processes of BC.
| A>I(G) RNA-Edited Site/Gene | Consequence | Phenotype of BC | Type of Study | Reference |
|---|---|---|---|---|
| Chr8:103841636/AZIN1 | S367G | Promote cell proliferation | Cell lines | [16] |
| Non-edited GABRA3 | I342M | Promote breast cancer cell migration, invasion and metastasis | Cell lines, animal models | [60,61] |
| Chr1:160302244/COPA | I164V | Promote cell viability, migration, and invasion | Cell lines | [56] |
| Chr3:58156064/FLNB | M2293V | Tune down the growth- and invasion-suppressing activities of FLNB | Cell lines | [54] |
| miR-140-3p target on DFFA | miRNA | Apoptosis | Cell lines | [62] |
| hsa-miR-200b target on ZEB1/2 and LIFR | miRNA | Worse patient survival cell invasion and migration by ZEB1/2 and LIFR inhibition. Negative correlation with TP53 |
Patients with BC Cell lines |
[63] |