Table 2.
A>I(G) RNA-edited sites involved in the drug response in BC.
| RNA-Edited Sites/Gene | Region | Drug Response | Type of Study | Reference |
|---|---|---|---|---|
| miR25-3p miR125a-3p/DHFR | miRNA | Resistance to methotrexate | In vitro | [69] |
| Chr19:58355670/ZNF587B | Coding | Resistant to doxorubicin | Cell line data | [70] |
| Chr20:36147563/BLCAP | Coding | Resistant to doxorubicin | Cell line data | [70] |
| Chr8:103841636/AZIN1 | Coding S367G | Low sensitivity to IGF-1 R BMS536924 | Patients with BC, in vitro | [56] |
| Chr4:158281294/GRIA2 | Coding R764G | High sensitivity to MEK Cl1040 | Patients with BC, in vitro | [56] |
| Chr13:46090371/COG3 | Coding I635V | High sensitivity to MEK Trametinib | Patients with BC, in vitro | [56] |