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Effects of coumestrol on the expression of ferroptosis pathway genes in CRC cells. Ferrous ions increased in both COLO 205 and HCT 116 cells after coumestrol treatment (A). The RT-PCR (B-C) and Western blot (D-E) analyses revealed that there was an increase in the expression of ferroptosis pathway-related genes, namely SLC39A8, NCOA4, VDAC2, and NOX2, at both the mRNA and protein levels following treatment with coumestrol.
