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. 2024 Jul 5;25(13):7406. doi: 10.3390/ijms25137406

Figure 7.

Figure 7

Tusc2-KO disrupts the frequency of NK and NKT cells in the CNS. (A) Representative contour dot plot graph comparing the differences in Ly49G+ NK cell population (CD11b+/CD3−/CD49+) between the Wild type (black) and the Tusc2 KO (red) males and females. (B) Tusc2 female KO mice showed a decrease in the proportion of NK cells (p = <0.0001) compared to their WT counterparts; KO males did not show a significant difference compared to WT males. (C) Representative contour dot plot graph comparing the differences in Ly49G+ NKT cell population (CD11b+/CD3+/CD49+) between the Wild type (black) and the Tusc2 KO (red) model in males and females. (D) NKT cell expression was significantly decreased in Tusc2 KO males (p = 0.0118) and in Tusc2 KO females (p = <0.0001). (E) Representative contour dot plot graph comparing the differences of B lymphocyte population (CD19+/CD25+) between the Wild type (black) and the Tusc2 KO (red) model in males and females. (F) The proportion of B cells was also evaluated. Tusc2 KO males had a significant decrease in B cells (p = 0.0343), and Tusc2 KO females showed a decrease in B cell proportions as well (p = <0.0001). Two-way ANOVA followed by Bonferroni’s multiple comparisons test. * p ≤ 0.05, ** p ≤ 0.01. n = 10 mice per group. For bar graphs, the black asterisk denotes comparisons between the WT and KO models, while the red asterisk represents the comparison between the sexes. “Percentage of population” indicates the proportion of all events in the population gating shown at the top of the graph.